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\begin{tikzpicture}[x=20bp,y=20bp]%
\clip (0,0) rectangle (10,10);
\path [draw,fill=black!25,ultra thick] (0,0) rectangle (10,10);
\path let \p1=(2,0), \p2=(2.4,0), \p3=(.4,0), \p4 = (.48,0) in
node at (5,5) {\sffamily\fontsize{\x1}{\x2}\selectfont \llap{1}$\times$\rlap{1}}
node at (5,2) {\sffamily\fontsize{\x3}{\x4}\selectfont (Original size: 200$\times$200 bp)}
;
\end{tikzpicture}%
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