\documentclass{testsuite} \usepackage{fontspec} \setmainfont[Color=FF0000]{Georgia} \def\1{abcABC}\def\2{XYZxyz} \def\test{\1\textsf{\2}\1\\} \begin{document} \setsansfont{Verdana} \test \setsansfont[Scale=0.5]{Verdana} \test \setsansfont[Scale=MatchLowercase]{Verdana} \test \setsansfont[Scale=MatchUppercase]{Verdana} \test \end{document}