%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% % ------------------------------------------------------------------------------------- % % - myChemistry - mychemistry_en.tex -------------------------------------------------- % % - Create reaction schemes with LaTeX and ChemFig ------------------------------------ % % ------------------------------------------------------------------------------------- % % - Clemens Niederberger -------------------------------------------------------------- % % - 2011/04/27 ------------------------------------------------------------------------ % % ------------------------------------------------------------------------------------- % % - http://www.niederberger-berlin.net/2011/02/latex-mychemistry/ --------------------- % % - kontakt@niederberger-berlin.net --------------------------------------------------- % % ------------------------------------------------------------------------------------- % % - If you have any ideas, questions, suggestions or bugs to report, please feel free - % % - to contact me. -------------------------------------------------------------------- % % ------------------------------------------------------------------------------------- % % - Copyright 2011 Clemens Niederberger - % % - - % % - This work may be distributed and/or modified under the - % % - conditions of the LaTeX Project Public License, either version 1.3 - % % - of this license or (at your option) any later version. - % % - The latest version of this license is in - % % - http://www.latex-project.org/lppl.txt - % % - and version 1.3 or later is part of all distributions of LaTeX - % % - version 2005/12/01 or later. - % % - - % % - This work has the LPPL maintenance status `maintained'. - % % - - % % - The Current Maintainer of this work is Clemens Niederberger. - % % - - % % - This work consists of the files mychemistry.sty, mychemistry_de.tex, - % % - mychemistry_en.tex, examples.tex - % % ------------------------------------------------------------------------------------- % %%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% \documentclass[DIV10,titlepage,toc=index]{scrartcl} %%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% % - Pakete ---------------------------------------------------------------------------- % %%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% \usepackage{standalone} \usepackage{scrhack} % verbessert KOMAs Zusammenspiel mit floats \usepackage{emerald} % Schriftarten \usepackage[utf8]{inputenx} % Zeichenkodierung: Eingabe \usepackage[T1]{fontenc} % Text-Ausgabe-Codierung \usepackage{textcomp,mathcomp} \usepackage[english]{babel} % Sprache \usepackage{xspace,paralist} % xspace und Listen \usepackage{siunitx} \DeclareSIUnit{\emlength}{em} \DeclareSIUnit{\pt}{pt} \sisetup{separate-uncertainty = true, exponent-product = \cdot, per-mode = symbol} \usepackage{listings,fancyvrb} % wortwörtliche Anzeige \newcommand{\vitem}[1][]{\SaveVerb[aftersave={\item[\textnormal{\UseVerb[#1]{vsave}}]}]{vsave}} \usepackage[perpage,multiple]{footmisc} % Fußnoten \usepackage[ngerman]{varioref} % flexibles Referenzieren \labelformat{section}{section #1} \labelformat{subsection}{section #1} \labelformat{subsubsection}{section #1} \usepackage[dvipsnames]{xcolor} % Farbe \colorlet{code}{RawSienna} \xdefinecolor{MyDarkRed}{rgb}{0.4392,0.0627,0.0627} %%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% % - Hyperlinks ------------------------------------------------------------------------ % %%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% \usepackage{hyperref} \hypersetup{colorlinks=true, % Setup der Hyperlinks und des pdf linkcolor=MyDarkRed!20!red, urlcolor=blue!70, plainpages=false, bookmarksopen=true, bookmarksopenlevel=2, bookmarksnumbered=true, pdfstartview=FitH, pdfauthor={Clemens Niederberger}, pdftitle={myChemistry - Examples}, pdfsubject={Create reaction schemes with LaTeX and ChemFig}, pdfkeywords={myChemistry}, pdfcreator={LaTeX} } \usepackage[english,color=MyDarkRed]{mychemistry} % myChemistry \renewcommand\thebeispiel{\arabic{beispiel}} % chemexec angepasst \labelformat{beispiel}{example #1} \labelformat{rxnfloat}{scheme #1} %%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% % - Listings anpassen ----------------------------------------------------------------- % %%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% \fvset{numbers=left,numbersep=3pt,xleftmargin=20pt,gobble=0,numberblanklines=true} \lstset{literate={ä}{{\"a}}1 {ö}{{\"o}}1 {ü}{{\"u}}1 {Ä}{{\"A}}1 {Ö}{{\"O}}1 {Ü}{{\"U}}1 {ß}{{\ss}}1} \lstset{ language=[LaTeX]TeX, basicstyle={\ttfamily}, % Grundstil extendedchars=true, numbers=left, % Zeilennummern numberstyle=\tiny, % Größe des Zeilennummern numberblanklines=true, % Leerzeilen nummerieren gobble=0, % das erste Leerzeichen abschneiden xleftmargin=20pt, % Einrückung links breaklines=true, % Zeilenumbruch moredelim=[is][\color{red!25!purple}]{!!}{!!},% Hervorhebung commentstyle={\color[named]{Gray}}, emph={begin,end}, % Umgebungen hervorheben emphstyle=\color{red}, keywordstyle=\color{code}, keywordstyle=[20]\color{blue}, morekeywords=[20]{rxn,rxnfloat,rxnscheme,tikzpicture}, texcsstyle=[30]\color{code}, moretexcs=[30]{anywhere,arrow,branch,chemabove,chemand,chembelow,chemfig,chemmove,chemname,chemrel,chemsign,ce,color,compound,declarecompound,draw,dummy,elmove,floatplacement,floatstyle,Hpl,Hyd,lewis,listof,makeinvisible,makevisible,marrow,mCsetup,merge,mesomeric,node,nu,om,op,ox,pgfpositionnodelater,reactant,restylefloat,setarrowlength,setarrowline,setatomsep,setatomsize,setbondlength,setbondshape,setcrambond,setmergelength,setrcndist,setrxnalign,setschemealign,setschemename,si,SI,textcolor,transition,vflipnext}, fancyvrb=true } %%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% % - Kopf- und Fußzeile ---------------------------------------------------------------- % %%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% \usepackage{scrpage2} \pagestyle{scrheadings} \setheadwidth{textwithmarginpar} \automark{section} \ihead{\mC v\mCversion} \ohead{\bfseries Examples} \ifoot{\small\color{gray}-~page~\thepage~-} \cfoot{} \ofoot{} %%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% % - Komascript ------------------------------------------------------------------------ % %%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% \setkomafont{disposition}{\rmfamily\bfseries} % Gewicht fett und Schriftart roman %%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% % - neue Befehle ---------------------------------------------------------------------- % %%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% % - weitere Makros -------------------------------------------------------------------- % \newcommand{\mC}{{\color{MyDarkRed}\ECFJD my\-Chemis\-try}\xspace} % Paketname \newcommand{\CF}{{\ECFAugie ChemFig}\xspace} % ChemFig in der originalen Schrift \newcommand{\eg}{\mbox{e.\,g.}\xspace} \newcommand{\TikZ}{\mbox{Ti{\bfseries\itshape k}Z}\xspace} \newcommand*\scrom{\scriptstyle\ominus} \newcommand*\scrop{\scriptstyle\oplus} \begin{document} \begin{titlepage} % inspired by the titlepage of chemfig's documentation \begin{tikzpicture}[remember picture,overlay] \shade [color=MyDarkRed,right color=white](current page.south west) rectangle ([yshift=3cm,xshift=-3cm]current page.center); \shade[top color=black,bottom color=MyDarkRed]([yshift=7cm]current page.east)rectangle([yshift=2.5cm]current page.west); \node[text width=\textwidth,opacity=.15,yshift=-5.3cm] at (current page.center) {% \begin{verbatim} \begin{rxn}[,.7] \setatomsep{1.5em}\footnotesize \reactant[,a]{ \chemfig{C(-[4]*6(=-=-=-))(-[2]*6(=-=-=-))(-[6,,,2]HO)-C(-[2]CH_3) (-[6]OH)-CH_3} } \arrow[a.20]{}{} \reactant[20]{ \chemfig{C(-[4]*6(=-=-=-))(-[2]*6(=-=-=-))(-[@{e1}6,,,2]H_2@{e2} \chembelow{O}{\oplus})-C(-[2]CH_3)(-[6]OH)-CH_3}\elmove{e1} {10:4mm}{e2}{-10:4mm} } \arrow[,,1.42]{$-\ce{H2O}$}{} \reactant{ \chemfig{\chembelow{C}{\oplus}(-[4]*6(=-=-=-))(-[2] *6(=-=-=-))-C(-[2]CH_3)(-[6]OH)-CH_3} } \arrow[a.-20,-|>]{}{} \reactant[-20]{ \chemfig{C(-[4]*6(=-=-=-))(-[2]*6(=-=-=-))(-[6,,,2]HO)-C(-[2]CH_3) (-[@{e3}6]@{e4}\chembelow{O}{\oplus}H_2)-CH_3}\elmove{e3} {170:4mm}{e4}{-170:4mm} } \arrow[,,1.42]{$-\ce{H2O}$}{} \reactant{ \chemfig{C(-[4]*6(=-=-=-))(-[2]*6(=-=-=-))(-[6,,,2]HO)- \chembelow{C}{\oplus}(-[2]CH_3)-CH_3} } \end{rxn} \end{verbatim}% }; \end{tikzpicture} \begin{center} \scalebox{4}{\mC}\par \Large v\mCversion\par\bigskip \footnotesize\mCdate{en}\par \normalsize Clemens Niederberger\par\vskip1.5cm \scalebox{3}{\color{white}Examples}% \end{center} \vskip3cm \begin{rxn}[,.7] \setatomsep{1.5em}\footnotesize \reactant[,a]{ \chemfig{C(-[4]*6(=-=-=-))(-[2]*6(=-=-=-))(-[6,,,2]HO)-C(-[2]CH_3)(-[6]OH)-CH_3} } \arrow[a.20]{}{} \reactant[20]{ \chemfig{C(-[4]*6(=-=-=-))(-[2]*6(=-=-=-))(-[@{e1}6,,,2]H_2@{e2}\chembelow{O}{\oplus})-C(-[2]CH_3)(-[6]OH)-CH_3}\elmove{e1}{10:4mm}{e2}{-10:4mm} } \arrow[,,1.42]{$-\ce{H2O}$}{} \reactant{ \chemfig{\chembelow{C}{\oplus}(-[4]*6(=-=-=-))(-[2]*6(=-=-=-))-C(-[2]CH_3)(-[6]OH)-CH_3} }{} \arrow[a.-20,-|>]{}{} \reactant[-20]{ \chemfig{C(-[4]*6(=-=-=-))(-[2]*6(=-=-=-))(-[6,,,2]HO)-C(-[2]CH_3)(-[@{e3}6]@{e4}\chembelow{O}{\oplus}H_2)-CH_3}\elmove{e3}{170:4mm}{e4}{-170:4mm} } \arrow[,,1.42]{$-\ce{H2O}$}{} \reactant{ \chemfig{C(-[4]*6(=-=-=-))(-[2]*6(=-=-=-))(-[6,,,2]HO)-\chembelow{C}{\oplus}(-[2]CH_3)-CH_3} } \end{rxn} \end{titlepage} \begin{abstract} Since the documentation is already long enough, I decided to provide an extra file containing only examples and a few words where to find possibly interesting code. \end{abstract} \listof{rxnfloat}{Example Schemes} \section{Addition Reaction}\label{sec:addition} A simple reaction scheme with two different products. \begin{rxnscheme}[,H]{Addition Reaction} \reactant{ \chemfig{=_[::-30]-[::60](=[::60]O)-[::-60]} } \arrow{ $+ \Hpl$ }{} \mesomeric[,rf]{ \reactant{ \chemfig{=_[:-30]-[::60](-[::60]OH)(-[::-120,.3,,,white]\oplus)-[::-60]} } \marrow[below] \reactant[below]{ \chemfig{\oplus-[6,.3,,,white]-[:-30]=_[::60](-[::60]OH)-[::-60]} } } \branch[right=of rf,,yshift=3em]{ \arrow{}{} \reactant{ \chemname{\chemfig{=_[:-30]-[::60](-[::60]OH)(-[::-120]R)-[::-60]}}{1,2-adduct} } } \branch[right=of rf,,yshift=-5em]{ \arrow{}{} \reactant{ \chemname{\chemfig{R-[6]-[:-30]=_[::60](-[::60]OH)-[::-60]}}{1,4-adduct} } } \end{rxnscheme} \begin{lstlisting} \begin{rxnscheme}[,H]{Addition Reaction} \reactant{ \chemfig{=_[::-30]-[::60](=[::60]O)-[::-60]} } \arrow{ $+ \Hpl$ }{} \mesomeric[,rf]{ \reactant{ \chemfig{=_[:-30]-[::60](-[::60]OH)(-[::-120,.3,,,white]\oplus)-[::-60]} } \marrow[below] \reactant[below]{ \chemfig{\oplus-[6,.3,,,white]-[:-30]=_[::60](-[::60]OH)-[::-60]} } } \branch[right=of rf,,yshift=3em]{ \arrow{}{} \reactant{ \chemname{\chemfig{=_[:-30]-[::60](-[::60]OH)(-[::-120]R)-[::-60]}}{1,2-adduct} } } \branch[right=of rf,,yshift=-5em]{ \arrow{}{} \reactant{ \chemname{\chemfig{R-[6]-[:-30]=_[::60](-[::60]OH)-[::-60]}}{1,4-adduct} } } \end{rxnscheme} \end{lstlisting} \section{Mesomerism} \begin{rxnscheme}[,H,,.8]{Mesomerism} \setatomsep{1.6em} \reactant[,start]{ \chemname{\chemfig{*6(-=-=(-[,,,,white]\phantom{Br})-=)}}{benzene \compound{benzene}} } \arrow[,,2.8]{}{} \reactant{ \chemname{\chemfig{*6(-=-=(-Br)-=)}}{bromobenzene \compound{bromobenzene}} } \arrow[start.below,,,pfeil_a]{\ce{Br2 / AlBr3}}{$-\ce{AlBr4\om}$} \mesomeric[pfeil_a.below,mesomerism,xshift=8.5em,yshift=-2.5em]{ \reactant{ \chemfig{*6(=[@{e1}]-=-(-[:120]Br)(-[:60]H)-(-[:-30,.4,,,white]\oplus)-[@{e2}])} \elmove{e1}{60:4mm}{e2}{0:4mm} } \marrow \reactant{ \chemfig{*6(-(-[:90,.4,,,white]\oplus)-[@{e4}]=[@{e3}]-(-[:120]Br)(-[:60]H)-=)} \elmove{e3}{180:4mm}{e4}{150:4mm} } \marrow \reactant{ \chemfig{*6(-=-(-[:-150,.4,,,white]\oplus)-(-[:120]Br)(-[:60]H)-=)} } } \branch[above=of mesomerism,,xshift=7.5em]{ \arrow[above]{$-\Hpl$}{} } \end{rxnscheme} If you put something relative to an arrow you might have to consider, that the arrow's anchor point is in the middle of the arrow. That's why \lstinline+\mesomeric+ is shifted with \lstinline+yshift=-2.5em+ in line 9. \begin{lstlisting} \begin{rxnscheme}[,H,,.8]{Mesomerism} \setatomsep{1.6em} % main reaction: \reactant[,start]{ \chemname{\chemfig{*6(-=-=(-[,,,,white]\phantom{Br})-=)}}{benzene \compound{benzene}} } \arrow[,,2.8]{}{} \reactant{ \chemname{\chemfig{*6(-=-=(-Br)-=)}}{bromobenzene \compound{bromobenzene}} } % branch: \arrow[start.below,,,pfeil_a]{\ce{Br2 / AlBr3}}{$-\ce{AlBr4\om}$} \mesomeric[!!pfeil_a.below!!,mesomerism,xshift=8.5em,!!yshift=-2.5em!!]{ \reactant{ \chemfig{*6(=[@{e1}]-=-(-[:120]Br)(-[:60]H)-(-[:-30,.4,,,white]\oplus)-[@{e2}])} \elmove{e1}{60:4mm}{e2}{0:4mm} } \marrow \reactant{ \chemfig{*6(-(-[:90,.4,,,white]\oplus)-[@{e4}]=[@{e3}]-(-[:120]Br)(-[:60]H)-=)} \elmove{e3}{180:4mm}{e4}{150:4mm} } \marrow \reactant{ \chemfig{*6(-=-(-[:-150,.4,,,white]\oplus)-(-[:120]Br)(-[:60]H)-=)} } } % last arrow inside a branch, since it cannot be shifted by itself: \branch[above=of mesomerism,,xshift=7.5em]{ \arrow[above]{$-\Hpl$}{} } \end{rxnscheme} \end{lstlisting} \section{The Titlepage} \begin{rxnscheme}[,,,.7]{The Titlepage} \setatomsep{1.5em}\footnotesize \reactant[,a]{ \chemfig{C(-[4]*6(=-=-=-))(-[2]*6(=-=-=-))(-[6,,,2]HO)-C(-[2]CH_3)(-[6]OH)-CH_3} } \arrow[a.20]{}{} \reactant[20]{ \chemfig{C(-[4]*6(=-=-=-))(-[2]*6(=-=-=-))(-[@{e1}6,,,2]H_2@{e2}\chembelow{O}{\oplus})-C(-[2]CH_3)(-[6]OH)-CH_3}\elmove{e1}{10:4mm}{e2}{-10:4mm} } \arrow[,,1.42]{$-\ce{H2O}$}{} \reactant{ \chemfig{\chembelow{C}{\oplus}(-[4]*6(=-=-=-))(-[2]*6(=-=-=-))-C(-[2]CH_3)(-[6]OH)-CH_3} }{} \arrow[a.-20,-|>]{}{} \reactant[-20]{ \chemfig{C(-[4]*6(=-=-=-))(-[2]*6(=-=-=-))(-[6,,,2]HO)-C(-[2]CH_3)(-[@{e3}6]@{e4}\chembelow{O}{\oplus}H_2)-CH_3}\elmove{e3}{170:4mm}{e4}{-170:4mm} } \arrow[,,1.42]{$-\ce{H2O}$}{} \reactant[,end]{ \chemfig{C(-[4]*6(=-=-=-))(-[2]*6(=-=-=-))(-[6,,,2]HO)-\chembelow{C}{\oplus}(-[2]CH_3)-CH_3} } \anywhere{below=of end}{} \end{rxnscheme} \begin{lstlisting} \begin{rxn}[,.7] \setatomsep{1.5em}\footnotesize % reaction above: \reactant[,a]{ \chemfig{C(-[4]*6(=-=-=-))(-[2]*6(=-=-=-))(-[6,,,2]HO)-C(-[2]CH_3)(-[6]OH)-CH_3} } \arrow[a.45]{}{} \reactant[45]{ \chemfig{C(-[4]*6(=-=-=-))(-[2]*6(=-=-=-))(-[@{e1}6,,,2]H_2@{e2}\chembelow{O}{\oplus})-C(-[2]CH_3)(-[6]OH)-CH_3}\elmove{e1}{10:4mm}{e2}{-10:4mm} } \arrow[,,1.42]{$-\ce{H2O}$}{} \reactant{ \chemfig{\chembelow{C}{\oplus}(-[4]*6(=-=-=-))(-[2]*6(=-=-=-))-C(-[2]CH_3)(-[6]OH)-CH_3} }{} % going down: \arrow[a.-45,-|>]{}{} \reactant[-45]{ \chemfig{C(-[4]*6(=-=-=-))(-[2]*6(=-=-=-))(-[6,,,2]HO)-C(-[2]CH_3)(-[@{e3}6]@{e4}\chembelow{O}{\oplus}H_2)-CH_3}\elmove{e3}{170:4mm}{e4}{-170:4mm} } \arrow[,,1.42]{$-\ce{H2O}$}{} \reactant{ \chemfig{C(-[4]*6(=-=-=-))(-[2]*6(=-=-=-))(-[6,,,2]HO)-\chembelow{C}{\oplus}(-[2]CH_3)-CH_3} } \end{rxn} \end{lstlisting} \section{Condensation Reaction} \begin{rxnscheme}[,H]{Condensation Reaction} \reactant{\chemfig{**6(---(-CH_2OH)-(-OH)--)}} \chemand \reactant{\chemfig{**6(----(-OH)-(-HOCH_2)-)}} \arrow[,-+>]{}{\ce{H2O}} \reactant{\chemfig{**6(---(-CH_2-[:-30]O-[:30]CH_2-[:-30]**6(-----(-OH)-))-(-OH)--)}} \arrow[-90,-+>,,dec]{}{\ce{CH2O}} \anywhere{dec.180,,xshift=-.2em}{\SI{200}{\celsius}} \reactant[-90,target]{\chemfig{**6(---(-CH_2-[:-30]**6(-----(-OH)-))-(-OH)--)}} \branch[left=of target]{ \reactant{\chemfig{**6(---(-CH_2OH)-(-OH)--)}} \chemand \reactant{\chemfig{**6(----(-OH)-(-H)-)}} \arrow[,-+>]{}{\ce{H2O}} } \end{rxnscheme} \begin{lstlisting} \begin{rxnscheme}[,H]{Condensation Reaction} \reactant{\chemfig{**6(---(-CH_2OH)-(-OH)--)}} \chemand \reactant{\chemfig{**6(----(-OH)-(-HOCH_2)-)}} \arrow[,-+>]{}{\ce{H2O}} \reactant{\chemfig{**6(---(-CH_2-[:-30]O-[:30]CH_2-[:-30]**6(-----(-OH)-))-(-OH)--)}} \arrow[-90,-+>,,dec]{}{\ce{CH2O}} \anywhere{dec.180,,xshift=-.2em}{\SI{200}{\celsius}} \reactant[-90,target]{\chemfig{**6(---(-CH_2-[:-30]**6(-----(-OH)-))-(-OH)--)}} \branch[left=of target]{ \reactant{\chemfig{**6(---(-CH_2OH)-(-OH)--)}} \chemand \reactant{\chemfig{**6(----(-OH)-(-H)-)}} \arrow[,-+>]{}{\ce{H2O}} } \end{rxnscheme} \end{lstlisting} \section{Substitution vs. Elimination} \begin{rxnscheme}[,H]{Substitution vs. Elimination} % first reaction: \reactant[,start_a]{\chemfig{@{H}H-[@{b1}:-60]\chemabove{C}{\scriptstyle\beta}(<[:-100]H)(<:[:-150]H)-[@{b2}]\chemabove{C}{\scriptstyle\alpha}(<[:20]H)(<:[:60]H)-[@{b3}:-60]@{X1}X}} \arrow{E2}{} \reactant{\chemfig{H-[:60]C(-[:120]H)=C(-[:60]H)-[:-60]H}} \chemand \reactant{\ce{X\om}} \chemand \reactant{\chemfig{O(-[:60]H)-[:-60]H}} % second reaction: \reactant[start_a.-90,start_b,yshift=-4em]{\chemfig{H-[:-60]C(<[:-100]H)(<:[:-150]H)-@{C}C(<[:20]H)(<:[:60]H)-[@{b4}:-60]@{X2}X}} \arrow{S$_\text{N}$2}{} \reactant{\chemfig{H-[:-60]C(<[:-100]H)(<:[:-150]H)-C(<[:-80]H)(<:[:-30]H)-[:60]OH}} \chemand \reactant{\ce{X\om}} % nucleophile/base: \anywhere{start_b.135,nuc,xshift=-3em,yshift=2em}{\chemfig{H-@{O}\chemabove{\lewis{026,O}}{\hspace{5mm}\scrom}}} % electron movements: \anywhere{nuc.0}{ \elmove{O}{90:1.5cm}{H}{180:1cm} \elmove{b1}{60:1cm}{b2}{90:5mm} \elmove{b3}{-170:5mm}{X1}{180:5mm} \elmove{O}{-90:1cm}{C}{100:1.5cm} \elmove{b4}{-170:5mm}{X2}{180:5mm} } \end{rxnscheme} You may see in line 20 that the \lstinline+\elmove+ commands are put inside of \lstinline+\anywhere+. This is necessary in order to produce the right scheme. But this time you can position \lstinline+\anywhere+ literally anywhere. \begin{lstlisting} \newcommand*\scrom{\scriptstyle\ominus} \begin{rxnscheme}[,H]{Substitution vs. Elimination} % first reaction: \reactant[,start_a]{\chemfig{@{H}H-[@{b1}:-60]\chemabove{C}{\scriptstyle\beta}(<[:-100]H)(<:[:-150]H)-[@{b2}]\chemabove{C}{\scriptstyle\alpha}(<[:20]H)(<:[:60]H)-[@{b3}:-60]@{X1}X}} \arrow{E2}{} \reactant{\chemfig{H-[:60]C(-[:120]H)=C(-[:60]H)-[:-60]H}} \chemand \reactant{\ce{X\om}} \chemand \reactant{\chemfig{O(-[:60]H)-[:-60]H}} % second reaction: \reactant[start_a.-90,start_b,yshift=-4em]{\chemfig{H-[:-60]C(<[:-100]H)(<:[:-150]H)-@{C}C(<[:20]H)(<:[:60]H)-[@{b4}:-60]@{X2}X}} \arrow{S$_\text{N}$2}{} \reactant{\chemfig{H-[:-60]C(<[:-100]H)(<:[:-150]H)-C(<[:-80]H)(<:[:-30]H)-[:60]OH}} \chemand \reactant{\ce{X\om}} % nucleophile/base: \anywhere{start_b.135,nuc,xshift=-3em,yshift=2em}{\chemfig{H-@{O}\chemabove{\lewis{026,O}}{\hspace{5mm}\scrom}}} % electron movements: \anywhere{nuc.0}{ \elmove{O}{90:1.5cm}{H}{180:1cm} \elmove{b1}{60:1cm}{b2}{90:5mm} \elmove{b3}{-170:5mm}{X1}{180:5mm} \elmove{O}{-90:1cm}{C}{100:1.5cm} \elmove{b4}{-170:5mm}{X2}{180:5mm} } \end{rxnscheme} \end{lstlisting} \section{Scheme with three Lines}\label{sec:three_lines} \begin{rxnscheme}{Scheme with three Lines} \setatomsep{1.5em} \footnotesize \reactant[,start]{\chemfig{EtO-(=[2]O)-[:-60](-Br)-[:-120](=[6]O)-[4]EtO}} \chemand \reactant{\chemfig{*6(-=-=-*5(-(=O)-\chemabove{\lewis{4:,N}}{\scrom}(-[4,.7,,,draw=none]\chemabove{K}{\scrop})-(=O)--)=)}} \arrow{}{} \reactant{\chemfig{*6(-=-=-*5(-(=O)-N(-(-[::-60](=[::-60]O)-[::60]EtO)-[::60](=[::60]O)-[::-60]EtO)-(=O)--)=)}} % newline, started with \anywhere: \anywhere{start.-90,a,xshift=-4em,yshift=-5em}{} \arrow[a.0,,.6]{\chemabove{\lewis{0:,B}}{\scrom}}{} \arrow{\ce{R-X}}{} \reactant{\chemfig{*6(-=-=-*5(-(=O)-N(-(-[4]R)(-[::-60](=[::-60]O)-[::60]EtO)-[::60](=[::60]O)-[::-60]EtO)-(=O)--)=)}} \arrow[,,1.25]{\Hpl/\ce{H2O}}{} \reactant{\chemfig{*6(-=-=-*5(-(=O)-N(-(-[4]R)(-[::-60](=[::-60]O)-[::60]HO_2C)-[::60](=[::60]O)-[::-60]HO_2C)-(=O)--)=)}} % newline, started with \anywhere: \anywhere{a.-90,b,yshift=-7em}{} \arrow[b.0]{\ce{- CO2}}{} \arrow{\Hpl}{\ce{H2O}} \reactant{\chemfig{R-(-[6]H)(-[2]C|O_2\om)-NH_3\op}} \end{rxnscheme} \begin{lstlisting} \newcommand*\scrom{\scriptstyle\ominus} \newcommand*\scrop{\scriptstyle\oplus} \begin{rxnscheme}{Scheme with three Lines} \setatomsep{1.5em} \footnotesize \reactant[,start]{\chemfig{EtO-(=[2]O)-[:-60](-Br)-[:-120](=[6]O)-[4]EtO}} \chemand \reactant{\chemfig{*6(-=-=-*5(-(=O)-\chemabove{\lewis{4:,N}}{\scrom}(-[4,.7,,,draw=none]\chemabove{K}{\scrop})-(=O)--)=)}} \arrow{}{} \reactant{\chemfig{*6(-=-=-*5(-(=O)-N(-(-[::-60](=[::-60]O)-[::60]EtO)-[::60](=[::60]O)-[::-60]EtO)-(=O)--)=)}} % newline, started with \anywhere: \anywhere{start.-90,a,xshift=-4em,yshift=-5em}{} \arrow[a.0,,.6]{\chemabove{\lewis{0:,B}}{\scrom}}{} \arrow{\ce{R-X}}{} \reactant{\chemfig{*6(-=-=-*5(-(=O)-N(-(-[4]R)(-[::-60](=[::-60]O)-[::60]EtO)-[::60](=[::60]O)-[::-60]EtO)-(=O)--)=)}} \arrow[,,1.25]{\Hpl/\ce{H2O}}{} \reactant{\chemfig{*6(-=-=-*5(-(=O)-N(-(-[4]R)(-[::-60](=[::-60]O)-[::60]HO_2C)-[::60](=[::60]O)-[::-60]HO_2C)-(=O)--)=)}} % newline, started with \anywhere: \anywhere{a.-90,b,yshift=-7em}{} \arrow[b.0]{\ce{- CO2}}{} \arrow{\Hpl}{\ce{H2O}} \reactant{\chemfig{R-(-[6]H)(-[2]C|O_2\om)-NH_3\op}} \end{rxnscheme} \end{lstlisting} \section{Hydratisation}\label{sec:hydratisation} \pgfdeclaredecoration{ddbond}{initial}{% \state{initial}[width=2pt]{% \pgfpathlineto{\pgfpoint{2pt}{0pt}}% \pgfpathmoveto{\pgfpoint{1.5pt}{2pt}}% \pgfpathlineto{\pgfpoint{2pt}{2pt}}% \pgfpathmoveto{\pgfpoint{2pt}{0pt}}% }% \state{final}{% \pgfpathlineto{\pgfpointdecoratedpathlast}% }% }% \tikzset{lddbond/.style={decorate,decoration=ddbond}}% \tikzset{rddbond/.style={decorate,decoration={ddbond,mirror}}}% \newcommand*\delm{\ensuremath{\text{\tiny$\delta\ominus$}}}% \newcommand*\delp{\ensuremath{\text{\tiny$\delta\oplus$}}}% A scheme with transition\index{transition} states. \begin{rxnscheme}{Hydratisation} \reactant[,carbonyl_A]{\chemfig{R_2C=O}} \anywhere{above=of carbonyl_A}{\chemfig{H-[:-30]O-[:30]H}} \arrow[,<=>]{\tiny slow}{} \transition[,transition_A]{\chemfig{R_2C(-[2,,2,,densely dotted]\chemabove{O}{\delp}(-[:150]H)-[:30]H)-[:-30,1.15,,,lddbond]O-[6,,,,densely dotted]H-[,,,,densely dotted]\chemabove{A}{\delm}}} \anywhere{below=of transition_A,,text width=3cm}{(general transition state, acid cat.)} \arrow[,<=>,.7]{}{} \reactant{\chemfig{R_2C(-[:60]\chemabove{O}{\scriptstyle\oplus}H_2)-[:-60]OH}} \arrow[below right,<=>,.7]{$-\Hpl$}{} \reactant[below right]{\chemfig{R_2C(-[:60]OH)-[:-60]OH}} \arrow[below left,<=>,.7]{}{\ce{H2O}} \reactant[below left,zw]{\chemfig{R_2C(-[:60]OH)-[:-60]O|\om}} \arrow[left,<=>,.7]{}{} \transition[left,transition_B]{\chemfig{R_2C(-[2,,2,,densely dotted]O(-[:150]H-[4,,,,densely dotted]\chemabove{B}{\delp})-[:30]H)-[:-30,1.15,,,lddbond]\chemabove{O}{\delm}-[6,,,,draw=none]\phantom{H}}} \anywhere{below=of transition_B,,text width=3cm}{(general transition state, base cat.)} \arrow[left,<=>]{}{\tiny slow} \reactant[left,carbonyl_B]{\chemfig{R_2C=O}} \anywhere{above=of carbonyl_B}{\chemfig{H-[:-30]O-[:30]H}} \end{rxnscheme} For this example we first declare a style for the delocalized double bonds: \begin{lstlisting} \pgfdeclaredecoration{ddbond}{initial}{% \state{initial}[width=2pt]{% \pgfpathlineto{\pgfpoint{2pt}{0pt}}% \pgfpathmoveto{\pgfpoint{1.5pt}{2pt}}% \pgfpathlineto{\pgfpoint{2pt}{2pt}}% \pgfpathmoveto{\pgfpoint{2pt}{0pt}}% }% \state{final}{% \pgfpathlineto{\pgfpointdecoratedpathlast}% }% }% \tikzset{lddbond/.style={decorate,decoration=ddbond}}% \tikzset{rddbond/.style={decorate,decoration={ddbond,mirror}}}% \end{lstlisting} Now the delocalized double bond can be used via \CF's fifth option (see the \CF manual): \begin{lstlisting} \chemfig{-[,,,,lddbond]-[,,,,rddbond]} \end{lstlisting} \chemfig{-[,,,,lddbond]-[,,,,rddbond]}\par\medskip Further we define the two commands \begin{lstlisting} \newcommand*\delm{\ensuremath{\text{\tiny$\delta\ominus$}}}% \newcommand*\delp{\ensuremath{\text{\tiny$\delta\oplus$}}}% \end{lstlisting} to use the partial charges without effort. Then the whole code looks like follows: \begin{lstlisting} \begin{rxnscheme}{Hydratisation} \reactant[,carbonyl_A]{\chemfig{R_2C=O}} \anywhere{above=of carbonyl_A}{\chemfig{H-[:-30]O-[:30]H}} \arrow[,<=>]{\tiny slow}{} \transition[,transition_A]{\chemfig{R_2C(-[2,,2,,densely dotted]\chemabove{O}{\delp}(-[:150]H)-[:30]H)-[:-30,1.15,,,lddbond]O-[6,,,,densely dotted]H-[,,,,densely dotted]\chemabove{A}{\delm}}} \anywhere{below=of transition_A,,text width=3cm}{(general transition state, acid cat.)} \arrow[,<=>,.7]{}{} \reactant{\chemfig{R_2C(-[:60]\chemabove{O}{\scriptstyle\oplus}H_2)-[:-60]OH}} \arrow[below right,<=>,.7]{$-\Hpl$}{} \reactant[below right]{\chemfig{R_2C(-[:60]OH)-[:-60]OH}} \arrow[below left,<=>,.7]{}{\ce{H2O}} \reactant[below left,zw]{\chemfig{R_2C(-[:60]OH)-[:-60]O|\om}} \arrow[left,<=>,.7]{}{} \transition[left,transition_B]{\chemfig{R_2C(-[2,,2,,densely dotted]O(-[:150]H-[4,,,,densely dotted]\chemabove{B}{\delp})-[:30]H)-[:-30,1.15,,,lddbond]\chemabove{O}{\delm}-[6,,,,draw=none]\phantom{H}}} \anywhere{below=of transition_B,,text width=3cm}{(general transition state, base cat.)} \arrow[left,<=>]{\tiny langsam}{} \reactant[left,carbonyl_B]{\chemfig{R_2C=O}} \anywhere{above=of carbonyl_B}{\chemfig{H-[:-30]O-[:30]H}} \end{rxnscheme} \end{lstlisting} You can see that \lstinline+\anywhere+ was used several times, either to place molecules or to label molecules. \section{Esterification}\label{sec:veresterung} \begin{rxnscheme}[,H]{Esterification} \reactant{\chemfig{H-C(=[:60]O)-[:-60]O-H}} \arrow[,-+>,1.5,protolysis]{\ce{H2SO4}}{\ce{HSO4\om}} \anywhere{below=of protolysis,,yshift=1em}{\tiny protolysis} \mesomeric{ \reactant{\chemfig{H-@{a2}C(-[:60]O-H)(-[:30,.5,,,draw=none]{\scriptstyle\oplus})-[:-60]O-H}} \marrow \reactant{\chemfig{H-C(=[:60]\chemabove{O}{\scriptstyle\oplus}-H)-[:-60]O-H}} } \branch[below,,xshift=-5em]{ \arrow[below,<=>]{\chemfig{H-[:120]@{a1}O-[:60]CH_3}}{\tiny addition} \reactant[below]{\chemfig{H-C(-[2]O-[:30]H)(-\chemabove{O}{\scriptstyle\oplus}(-[:60]CH_3)-[:-60]H)-[6]O-[:-30]H}\elmove{a1}{90:1.5cm}{a2}{0:3cm}} } \branch[left,,yshift=-3.5em]{ \arrow[left,<=>]{}{\tiny protolysis} } \reactant[left]{\chemfig{H-C(-[2]O-[:30]H)(-O-CH_3)-[@{b1}6]@{a3}\chemabove{O}{\hspace*{-4mm}\scriptstyle\oplus}(-[:-150]H)-[:-30]H}\elmove{b1}{0:5mm}{a3}{20:5mm}} \arrow[below,<=>]{\ce{- H2O}}{\tiny elimination} \mesomeric[below,,xshift=6em]{ \reactant{\chemfig{H-C(-[:60]O-H)(-[,.5,,,draw=none]{\scriptstyle\oplus})-[:-60]O-CH_3}} \marrow \reactant{\chemfig{H-C(=[:60]\chemabove{O}{\scriptstyle\oplus}-H)-[:-60]O-CH_3}} } \arrow[,-+>,1.5]{\ce{HSO4\om}}{\ce{H2SO4}} \reactant{\chemfig{H-C(=[:60]O)-[:-60]O-CH_3}} \end{rxnscheme} \begin{lstlisting} \begin{rxn}{Esterification} \reactant{\chemfig{H-C(=[:60]O)-[:-60]O-H}} \arrow[,-+>,1.2,protolysis]{\ce{H2SO4}}{\ce{HSO4\om}} \anywhere{below=of protolysis,,yshift=1em}{\tiny protolysis} \mesomeric{ \reactant{\chemfig{H-@{a2}C(-[:60]O-H)(-[:30,.5,,,draw=none]{\scriptstyle\oplus})-[:-60]O-H}} \marrow \reactant{\chemfig{H-C(=[:60]\chemabove{O}{\scriptstyle\oplus}-H)-[:-60]O-H}} } \branch[below,,xshift=-5em]{ \arrow[below,<=>]{\tiny addition}{\chemfig{H-[:120]@{a1}O-[:60]CH_3}} \reactant[below]{ \chemfig{H-C(-[2]O-[:30]H)(-\chemabove{O}{\scriptstyle\oplus}(-[:60]CH_3)-[:-60]H)-[6]O-[:-30]H} \elmove{a1}{90:1.5cm}{a2}{0:3cm} } } \branch[left,,yshift=-3.5em]{ \arrow[left,<=>]{}{\tiny protolysis} } \reactant[left]{ \chemfig{H-C(-[2]O-[:30]H)(-O-CH_3)-[@{b1}6]@{a3}\chemabove{O}{\hspace*{-4mm}\scriptstyle\oplus}(-[:-150]H)-[:-30]H} \elmove{b1}{0:5mm}{a3}{20:5mm} } \arrow[below,<=>]{\ce{- H2O}}{\tiny elimination} \mesomeric[below,,xshift=6em]{ \reactant{\chemfig{H-C(-[:60]O-H)(-[,.5,,,draw=none]{\scriptstyle\oplus})-[:-60]O-CH_3}} \marrow \reactant{\chemfig{H-C(=[:60]\chemabove{O}{\scriptstyle\oplus}-H)-[:-60]O-CH_3}} } \arrow[,-+>,1.2]{\ce{HSO4\om}}{\ce{H2SO4}} \reactant{\chemfig{H-C(=[:60]O)-[:-60]O-CH_3}} \end{rxnscheme} \end{lstlisting} \newpage \section{Electrophilic Addition}\label{sec:elektrophile_addition} This scheme forms a circle. \begin{rxnscheme}[,H]{Electrophilic Addition} \setarrowlength{3em} \reactant{\chemfig{>[:-20]C(<[:40])=[6]C(<[:-130])<[:-20]}} \chemand[,plus] \reactant{\chemfig{\lewis{246,Br}-\lewis{026,Br}}} \arrow[plus.-90,<=>]{\footnotesize fast}{} \reactant[-90,attack]{\chemfig{>[:-20]C(<[:40])=[@{db}6]C(<[:-130])<[:-20]}} \anywhere{right=of attack}{ \chemfig{@{Br1}\lewis{246,Br}-[@{b2}]@{Br2}\lewis{026,Br}} \elmove{db}{20:5mm}{Br1}{135:5mm} \elmove{b2}{-120:5mm}{Br2}{-120:5mm} } % to the left: \arrow[attack.-135,<=>,2]{\ce{- Br\om}}{\footnotesize slow} \reactant[-135,carbenium_a]{\vflipnext\chemfig{-[:-30]\chembelow{C}{\scriptstyle\oplus}(-[:30])-[6]C(<[:-150])(<:[:-100])-[:-30]\lewis{137,Br}}} \anywhere{below=of carbenium_a}{\footnotesize carbenium ion} \arrow[,<<=>]{}{} \reactant[,bromonium]{\chemfig{>:[:-60]C?(<[:160])-[6]C(<[:-110])(<:[:-150])-[:30]\lewis{17,Br}?-[4,.5,,,draw=none]{\scriptstyle\oplus}}} \anywhere{below=of bromonium,,yshift=.35em}{\footnotesize bromonium ion} % to the right: \arrow[attack.-45,<=>,2]{\footnotesize slow}{\ce{- Br\om}} \reactant[-45,carbenium_b]{\chemfig{-[:-30]\chemabove{C}{\scriptstyle\oplus}(-[:30])-[6]C(<:[:-150])(<[:-100])-[:-30]\lewis{157,Br}}} \anywhere{below=of carbenium_b}{\footnotesize carbenium ion} \arrow[left,<<=>]{}{} \mCsetup{reset} \end{rxnscheme} \begin{lstlisting} \begin{rxnscheme}[,H]{Electrophilic Addition} \setarrowlength{3em} \reactant{\chemfig{>[:-20]C(<[:40])=[6]C(<[:-130])<[:-20]}} \chemand[,plus] \reactant{\chemfig{\lewis{246,Br}-\lewis{026,Br}}} \arrow[plus.-90,<=>]{\footnotesize fast}{} \reactant[-90,attack]{\chemfig{>[:-20]C(<[:40])=[@{db}6]C(<[:-130])<[:-20]}} \anywhere{right=of attack}{ \chemfig{@{Br1}\lewis{246,Br}-[@{b2}]@{Br2}\lewis{026,Br}} \elmove{db}{20:5mm}{Br1}{135:5mm} \elmove{b2}{-120:5mm}{Br2}{-120:5mm} } % to the left: \arrow[attack.-135,<=>,2]{\ce{- Br\om}}{\footnotesize slow} \reactant[-135,carbenium_a]{\vflipnext\chemfig{-[:-30]\chembelow{C}{\scriptstyle\oplus}(-[:30])-[6]C(<[:-150])(<:[:-100])-[:-30]\lewis{137,Br}}} \anywhere{below=of carbenium_a}{\footnotesize carbenium ion} \arrow[,<<=>]{}{} \reactant[,bromonium]{\chemfig{>:[:-60]C?(<[:160])-[6]C(<[:-110])(<:[:-150])-[:30]\lewis{17,Br}?-[4,.5,,,draw=none]{\scriptstyle\oplus}}} \anywhere{below=of bromonium,,yshift=.35em}{\footnotesize bromonium ion} % to the right: \arrow[attack.-45,<=>,2]{\footnotesize slow}{\ce{- Br\om}} \reactant[-45,carbenium_b]{\chemfig{-[:-30]\chemabove{C}{\scriptstyle\oplus}(-[:30])-[6]C(<:[:-150])(<[:-100])-[:-30]\lewis{157,Br}}} \anywhere{below=of carbenium_b}{\footnotesize carbenium ion} \arrow[left,<<=>]{}{} \mCsetup{reset} \end{rxnscheme} \end{lstlisting} \section{Activation of Fatty Acids}\label{sec:activation_fatty_acid} \begin{rxnscheme}[,H]{Activation of Fatty Acids} \reactant[,ATP]{\chemfig{\chemabove{O}{\hspace*{-5mm}\scrom}-P(=[2]O)(-[6]\chembelow{O}{\scrom})-O-P(=[2]O)(-[6]\chembelow{O}{\scrom})-@{O1}O-[@{b1}]@{P}P(=[2]O)(-[6]\chembelow{O}{\scrom})-O-CH_2-[6,1.5,1](-[6,.5])(-[:20,1.3]O?[a])<[7](-[2,.5])(-[6]OH)-[,,,,line width=3pt](-[2,.5])(-[6]OH)>[1]?[a](-[6,.5])-[2,1.5]N?[b]-[:18]([:30]*6(-N=-N=(-NH_2)-=))-[:90]-[:162]N=^[:-126]?[b]}} \anywhere{below right=of ATP,,xshift=-4em,yshift=3em}{\bfseries ATP} \arrow[below,,1.5]{}{\chemname{\chemfig{R-C(=[:-60]O)-[:60]@{O2}O-[@{b2}]H}}{fatty acid}} \branch[on chain=going below]{ \reactant[,pyrophosphat]{ \chemfig{\chemabove{O}{\hspace*{-5mm}\scrom}-P(=[2]O)(-[6]\chembelow{O}{\scrom})-O-P(=[2]O)(-[6]\chembelow{O}{\scrom})-\chemabove{O}{\hspace*{5mm}\scrom}} \elmove{b1}{100:1cm}{O1}{90:5mm} \elmove{O2}{135:1cm}{P}{-135:1cm} \elmove{b2}{-90:5mm}{O2}{-60:5mm} } \anywhere{below=of pyrophosphat}{pyrophosphate PP$_\text{i}$} \chemand \reactant[,acyl-amp]{\chemfig{R-@{C}C(=[:-60]O)-[@{b3}:60]@{O3}O-P(-[6]\chembelow{O}{\scrom})(=[2]O)-O-CH_2-[6,,1,1]r|ibos|e-[2,1.05,3,1]a|denine}} \anywhere{below=of acyl-amp}{\bfseries acyl-AMP} } \branch[on chain=going below,,xshift=-8em]{ \arrow[below]{\ce{H2O}}{} \reactant[below,Pi]{2~\chemfig{HO-P(=[2]O)(-[6]\chembelow{O}{\scrom})-O}} \anywhere{below right=of Pi}{P$_\text{i}$} } \branch[,,xshift=4em]{ \arrow[below,-+>]{\chemfig{CoA-@{S}S-[@{b4}:-60]H}}{AMP} \reactant[below,acyl-SCoA]{ \chemfig{R-C(=[:-60]O)-[:60]S-CoA} \elmove{S}{45:3cm}{C}{-120:2cm} \elmove{b3}{135:5mm}{O3}{110:7mm} \elmove{b4}{-120:7mm}{S}{-100:5mm} } \anywhere{below=of acyl-SCoA}{acyl-SCoA} } \end{rxnscheme} \begin{lstlisting} \def\scrom{\scriptstyle\ominus} \begin{rxnscheme}[,H]{Activation of Fatty Acids} \reactant[,ATP]{\chemfig{\chemabove{O}{\hspace*{-5mm}\scrom}-P(=[2]O)(-[6]\chembelow{O}{\scrom})-O-P(=[2]O)(-[6]\chembelow{O}{\scrom})-@{O1}O-[@{b1}]@{P}P(=[2]O)(-[6]\chembelow{O}{\scrom})-O-CH_2-[6,1.5,1](-[6,.5])(-[:20,1.3]O?[a])<[7](-[2,.5])(-[6]OH)-[,,,,line width=3pt](-[2,.5])(-[6]OH)>[1]?[a](-[6,.5])-[2,1.5]N?[b]-[:18]([:30]*6(-N=-N=(-NH_2)-=))-[:90]-[:162]N=^[:-126]?[b]}} \anywhere{below right=of ATP,,xshift=-4em,yshift=3em}{\bfseries ATP} \arrow[below,,1.5]{\chemname{\chemfig{R-C(=[:-60]O)-[:60]@{O2}O-[@{b2}]H}}{fatty acid}}{} \branch[on chain=going below]{ \reactant[,pyrophosphat]{ \chemfig{\chemabove{O}{\hspace*{-5mm}\scrom}-P(=[2]O)(-[6]\chembelow{O}{\scrom})-O-P(=[2]O)(-[6]\chembelow{O}{\scrom})-\chemabove{O}{\hspace*{5mm}\scrom}} \elmove{b1}{100:1cm}{O1}{90:5mm} \elmove{O2}{135:1cm}{P}{-135:1cm} \elmove{b2}{-90:5mm}{O2}{-60:5mm} } \anywhere{below=of pyrophosphat}{pyrophosphate PP$_\text{i}$} \chemand \reactant[,acyl-amp]{\chemfig{R-@{C}C(=[:-60]O)-[@{b3}:60]@{O3}O-P(-[6]\chembelow{O}{\scrom})(=[2]O)-O-CH_2-[6,,1,1]r|ibos|e-[2,1.05,3,1]A|denine}} \anywhere{below=of acyl-amp}{\bfseries acyl-AMP} } \branch[on chain=going below,,xshift=-8em]{ \arrow[below]{\ce{H2O}}{} \reactant[below,Pi]{2~\chemfig{HO-P(=[2]O)(-[6]\chembelow{O}{\scrom})-O}} \anywhere{below right=of Pi}{P$_\text{i}$} } \branch[,,xshift=4em]{ \arrow[below,-+>]{\chemfig{CoA-@{S}S-[@{b4}:-60]H}}{AMP} \reactant[below,acyl-SCoA]{ \chemfig{R-C(=[:-60]O)-[:60]S-CoA} \elmove{S}{135:2cm}{C}{-135:1cm} \elmove{b3}{-45:5mm}{O3}{-70:7mm} \elmove{b4}{-120:7mm}{S}{-100:5mm} } \anywhere{below=of acyl-SCoA}{acyl-SCoA} } \end{rxnscheme} \end{lstlisting} \section{Change the layout with \TikZ}\label{sec:tikz_layout} \begin{rxnscheme}{Change the layout with \TikZ} \colorlet{mCgreen}{green!50!gray} \colorlet{mCblue}{cyan!50!gray} \colorlet{mCred}{magenta!50!gray} \tikzset{reactant/.style={draw=#1,fill=#1!10,minimum width=.8\textwidth,inner sep=1em,rounded corners}} \mCsetup{arrowlength=3em,arrowline=very thick} \reactant[,,reactant=mCgreen]{ \chemname{\chemfig{Alky|l--[6](-[4,,,2]Acy|l)-[6]-O-P(=[2]O)(-[6]O|\om)-O-[:-30]-[:30]-[:-30]NH_2}}{\bfseries Phosphatidylethanolamine} } \arrow[below]{\textit{N}-acyltransferase}{} \reactant[below,,reactant=mCblue]{ \chemname{\chemfig{Alky|l--[6](-[4,,,2]Acy|l)-[6]-O-P(=[2]O)(-[6]O|\om)-O-[:-30]-[:30]-[:-30]\chembelow{N}{H}-[:30](=[2]O)-[:-30]-[:30]-[:-30]-[:30]=_-[:-30]-[:30]=_-[:-60]-[::-60]=_[:180]-[::-30]-[::60]=_[:180]-[::-30]-[::60]-[::-60]-[::60]-[6]}}{\bfseries\textit{N}-arachidonoyl-PE} } \arrow[below]{Phospholipase D}{} \reactant[below,,reactant=mCred]{ \chemname{\chemfig{HO-[:-30]-[:30]-[:-30]\chembelow{N}{H}-[:30](=[2]O)-[:-30]-[:30]-[:-30]-[:30]=_-[:-30]-[:30]=_-[:-60]-[::-60]=_[:180]-[::-30]-[::60]=_[:180]-[::-30]-[::60]-[::-60]-[::60]-[6]}}{\bfseries Anandamide} } \mCsetup{reset} \end{rxnscheme} This is an example for the usage of the \lstinline++ option. Please take a closer look at lines \numlist{5;7;11;15}. \begin{lstlisting} \begin{rxnscheme}{Change the layout with \TikZ} \colorlet{mCgreen}{green!50!gray} \colorlet{mCblue}{cyan!50!gray} \colorlet{mCred}{magenta!50!gray} !!\tikzset{reactant/.style={draw=#1,fill=#1!10,minimum width=.8\textwidth,inner sep=1em,rounded corners}}!! \mCsetup{arrowlength=3em,arrowline=very thick} \reactant[,,!!reactant=mCgreen!!]{ \chemname{\chemfig{Alky|l--[6](-[4,,,2]Acy|l)-[6]-O-P(=[2]O)(-[6]O|\om)-O-[:-30]-[:30]-[:-30]NH_2}}{\bfseries Phosphatidylethanolamine} } \arrow[below]{}{\textit{N}-acyltransferase} \reactant[below,,!!reactant=mCblue!!]{ \chemname{\chemfig{Alky|l--[6](-[4,,,2]Acy|l)-[6]-O-P(=[2]O)(-[6]O|\om)-O-[:-30]-[:30]-[:-30]\chembelow{N}{H}-[:30](=[2]O)-[:-30]-[:30]-[:-30]-[:30]=_-[:-30]-[:30]=_-[:-60] -[::-60]=_[:180]-[::-30]-[::60]=_[:180]-[::-30]- [::60]-[::-60]-[::60]-[6]}}{\bfseries\textit{N}-arachidonoyl-PE} } \arrow[below]{}{Phospholipase D} \reactant[below,,!!reactant=mCred!!]{ \chemname{\chemfig{HO-[:-30]-[:30]-[:-30]\chembelow{N}{H}-[:30](=[2]O)-[:-30]-[:30]-[:-30]-[:30]=_-[:-30]-[:30]=_-[:-60] -[::-60]=_[:180]-[::-30]-[::60]=_[:180]-[::-30]- [::60]-[::-60]-[::60]-[6]}}{\bfseries Anandamide} } \mCsetup{reset} \end{rxnscheme} \end{lstlisting} \section{Claisen-Kondensation} \begin{rxnscheme}{Claisen-Kondensation} \colorlet{mCred}{red!50!gray} \setatomsep{1.5em} % Ergebnis: \branch[,one,draw=mCred,fill=mCred!10,rounded corners,inner sep=.5em]{ \reactant{\chemfig{[:30]-(=[2]O)-[:-30]O--[:-30]}} \chemand \reactant{\chemfig{[:30]-(=[2]O)-[:-30]O--[:-30]}} \arrow[,,2]{\ce{NaOEt}, \ce{EtOH}}{} \reactant{\chemfig{[:30]-(=[2]O)-[:-30]-(=[2]O)-[:-30]O--[:-30]}} } % Mechanismus: \branch[-90,,xshift=-13.5em]{ \arrow[-90,<<=>]{\ce{{}\om OEt}}{} } \mesomeric[-90,two,xshift=4.5em]{ \reactant{\chemfig{[:30](-[:150,.3,,,draw=none]@{C1}\scriptstyle\ominus)-(=[2]O)-[:-30]O--[:-30]}} \marrow \reactant{\chemfig{[:30]=(-[2]O|\om)-[:-30]O--[:-30]}} } \chemand \reactant{\ce{EtOH}} \branch[two.-90,three,xshift=-5.5em]{ \arrow[-90,<=>,,,both]{\chemfig[][scale=.7]{[:30]-@{C2}(=[@{b1}2]O@{O1})-[:-30]O--[:-30]}}{} } \reactant[three.-90]{\chemfig{-(-[@{b2}2]@{O2}O|\om)(-[6]-[:-30](=[6]O)-[:30]O-[:-30]-[:30])-[@{b3}]@{O3}O-[:30]-[:-30]}} \arrow[,<=>]{}{} \reactant[,four]{\chemfig{[:30]-(=[2]O)-[:-30]@{C3}(-[:-120]H)(-[@{b4}:-60]H@{H})-(=[2]O)-[:-30]O--[:-30]}} \chemand \reactant{\chemfig{\om @{O4}OEt}} \arrow[four.-90]{}{} \mesomeric[-90]{ \reactant{\chemfig{[:30]-(=[2]O)-[:-30]=(-[2]O|\om)-[:-30]O--[:-30]}} \marrow \reactant{\chemfig{[:30]-(=[2]O)-[:-30](-[6,.3,,,draw=none]\scriptstyle\ominus)-(=[2]O)-[:-30]O--[:-30]}} \marrow \reactant{\chemfig{[:30]-(-[2]O|\om)=[:-30]-(=[2]O)-[:-30]O--[:-30]}} } \arrow[-90]{\Hpl, \ce{H2O}}{} \reactant[-90]{\chemfig{[:30]-(=[2]O)-[:-30]-(=[2]O)-[:-30]O--[:-30]}} \anywhere{one.0}{ \elmove{C1}{-100:2cm}{C2}{-90:2cm} \elmove{b1}{10:5mm}{O1}{0:5mm} \elmove{O2}{180:5mm}{b2}{180:5mm} \elmove{b3}{80:5mm}{O3}{90:5mm} \elmove{b4}{0:5mm}{C3}{0:7mm} \elmove{O4}{-90:1cm}{H}{-45:1cm} } \end{rxnscheme} \begin{lstlisting} \begin{rxnscheme}{Claisen-Kondensation} \colorlet{mCred}{red!50!gray} \setatomsep{1.5em} % Ergebnis: \branch[,one,draw=mCred,fill=mCred!10,rounded corners,inner sep=.5em]{ \reactant{\chemfig{[:30]-(=[2]O)-[:-30]O--[:-30]}} \chemand \reactant{\chemfig{[:30]-(=[2]O)-[:-30]O--[:-30]}} \arrow[,,2]{\ce{NaOEt}, \ce{EtOH}}{} \reactant{\chemfig{[:30]-(=[2]O)-[:-30]-(=[2]O)-[:-30]O--[:-30]}} } % Mechanismus: \branch[-90,,xshift=-13.5em]{ \arrow[-90,<=>]{\ce{{}\om OEt}}{} } \mesomeric[-90,two,xshift=4.5em]{ \reactant{\chemfig{[:30](-[:150,.3,,,draw=none]@{C1}\scriptstyle\ominus)-(=[2]O)-[:-30]O--[:-30]}} \marrow \reactant{\chemfig{[:30]=(-[2]O|\om)-[:-30]O--[:-30]}} } \chemand \reactant{\ce{EtOH}} \branch[two.-90,three,xshift=-5.5em]{ \arrow[-90,<=>,,,both]{\chemfig[][scale=.7]{[:30]-@{C2}(=[@{b1}2]O@{O1})-[:-30]O--[:-30]}}{} } \reactant[three.-90]{\chemfig{-(-[@{b2}2]@{O2}O|\om)(-[6]-[:-30](=[6]O)-[:30]O-[:-30]-[:30])-[@{b3}]@{O3}O-[:30]-[:-30]}} \arrow[,<=>]{}{} \reactant[,four]{\chemfig{[:30]-(=[2]O)-[:-30]@{C3}(-[:-120]H)(-[@{b4}:-60]H@{H})-(=[2]O)-[:-30]O--[:-30]}} \chemand \reactant{\chemfig{\om @{O4}OEt}} \arrow[four.-90]{}{} \mesomeric[-90]{ \reactant{\chemfig{[:30]-(=[2]O)-[:-30]=(-[2]O|\om)-[:-30]O--[:-30]}} \marrow \reactant{\chemfig{[:30]-(=[2]O)-[:-30](-[6,.3,,,draw=none]\scriptstyle\ominus)-(=[2]O)-[:-30]O--[:-30]}} \marrow \reactant{\chemfig{[:30]-(-[2]O|\om)=[:-30]-(=[2]O)-[:-30]O--[:-30]}} } \arrow[-90]{\Hpl, \ce{H2O}}{} \reactant[-90]{\chemfig{[:30]-(=[2]O)-[:-30]-(=[2]O)-[:-30]O--[:-30]}} \anywhere{one.0}{ \elmove{C1}{-100:2cm}{C2}{-90:2cm} \elmove{b1}{10:5mm}{O1}{0:5mm} \elmove{O2}{180:5mm}{b2}{180:5mm} \elmove{b3}{80:5mm}{O3}{90:5mm} \elmove{b4}{0:5mm}{C3}{0:7mm} \elmove{O4}{-90:1cm}{H}{-45:1cm} } \end{rxnscheme} \end{lstlisting} \section{Extensive Synthesis}\label{sec:tikzsynthese} As last example we can create extensive syntheses, using the \lstinline=\merge= command. \begin{rxnscheme}[,,,.8]{Extensive Synthesis} \setatomsep{1.5em} \branch[,start_left]{ \reactant{\chemfig{=_[::30]-[::-60]-[::60](-[::-60])(-[::120])-[::0]OH}} \arrow[below]{\ce{HBr}}{} \reactant[below]{\chemfig{Br-[::30]-[::-60]=_[::60](-[::-60])-[::60]}} } \branch[right=of start_left,start_center,yshift=1em]{ \reactant{\chemname{\chemfig[][scale=.8]{**6(--(-SO_2Cl)---(-)-)}}{tosyle chloride}} \arrow[below]{\ce{NaOH}}{\ce{Zn}} \reactant[below]{\chemfig[][scale=.8]{**6(--(-SO_2Na)---(-)-)}} } \branch[right=of start_center,start_right,xshift=3em,yshift=-10em]{ \reactant{\chemname{\chemfig{-[::30](-[::60])=_[::-60]-[::60]COOH}}{3-methyl-2-butenoic acid}} \arrow[below]{\ce{CH3OH}}{} \reactant[below]{\chemfig{-[::30](-[::60])=_[::-60]-[::60]CO_2CH_3}} } \branch[below=of start_left,target_one,xshift=5em,yshift=-5em]{ \reactant{\chemfig[][scale=.8]{**6(--(-SO_2-[:30]-[::-60]=_[::60](-[::60])-[::-60])---(-)-)}} } \branch[below=of target_one,target_two,xshift=6em,yshift=-6em]{ \mesomeric{\chemfig[][scale=.8]{-[::30](-[::60])=^[::-60]-[::60](-[::60]S(=[::90]O)(=[::-90]O)-[::0]**6(---(-)---))-[::-60](-[::0])(-[::-120])-[::60](-[::60,.5,,,white]\ominus)-[::-60]CO_2CH_3}} \arrow[below,,.5]{}{} \arrow[below,,.5]{\ce{KOH}}{} \reactant[below]{\chemname{\chemfig{-[::-30](-[::-60])=^[::60]>[::-60](-[::90,1.2])-[::30,1.2](-[::120,1.2](-[::-60])-[::0])<:[::-30]COOH}}{\emph{trans}-chrysanthemum acid}} } \merge{target_one}{start_left}{start_center} \merge[\ce{NaOCH3}]{target_two}{target_one}{start_right} \end{rxnscheme} \begin{lstlisting} \begin{rxnscheme}[,,,.8]{Extensive Synthesis} \setatomsep{1.5em} \branch[,start_left]{ \reactant{\chemfig{=_[::30]-[::-60]-[::60](-[::-60])(-[::120])-[::0]OH}} \arrow[below]{\ce{HBr}}{} \reactant[below]{\chemfig{Br-[::30]-[::-60]=_[::60](-[::-60])-[::60]}} } \branch[right=of start_left,start_center,yshift=1em]{ \reactant{\chemname{\chemfig[][scale=.8]{**6(--(-SO_2Cl)---(-)-)}}{tosyle chloride}} \arrow[below]{\ce{NaOH}}{\ce{Zn}} \reactant[below]{\chemfig[][scale=.8]{**6(--(-SO_2Na)---(-)-)}} } \branch[right=of start_center,start_right,xshift=3em,yshift=-10em]{ \reactant{\chemname{\chemfig{-[::30](-[::60])=_[::-60]-[::60]COOH}}{3-methyl-2-butenoic acid}} \arrow[below]{\ce{CH3OH}}{} \reactant[below]{\chemfig{-[::30](-[::60])=_[::-60]-[::60]CO_2CH_3}} } \branch[below=of start_left,target_one,xshift=5em,yshift=-5em]{ \reactant{\chemfig[][scale=.8]{**6(--(-SO_2-[:30]-[::-60]=_[::60](-[::60])-[::-60])---(-)-)}} } \branch[below=of target_one,target_two,xshift=6em,yshift=-6em]{ \mesomeric{\chemfig[][scale=.8]{-[::30](-[::60])=^[::-60]-[::60](-[::60]S(=[::90]O)(=[::-90]O)-[::0]**6(---(-)---))-[::-60](-[::0])(-[::-120])-[::60](-[::60,.5,,,white]\ominus)-[::-60]CO_2CH_3}} \arrow[below,,.5]{}{} \arrow[below,,.5]{\ce{KOH}}{} \reactant[below]{\chemname{\chemfig{-[::-30](-[::-60])=^[::60]>[::-60](-[::90,1.2])-[::30,1.2](-[::120,1.2](-[::-60])-[::0])<:[::-30]COOH}}{\emph{trans}-chrysanthemum acid}} } \merge{target_one}{start_left}{start_center} \merge[\ce{NaOCH3}]{target_two}{target_one}{start_right} \end{rxnscheme} \end{lstlisting} Let's go through the code, piece by piece. \begin{lstlisting} \begin{rxnscheme}[,,,.8]{Extensive Synthesis} \setatomsep{1.5em} \branch[,start_left]{ \reactant{\chemfig{=_[::30]-[::-60]-[::60](-[::-60])(-[::120])-[::0]OH}} \arrow[below]{\ce{HBr}}{} \reactant[below]{\chemfig{Br-[::30]-[::-60]=_[::60](-[::-60])-[::60]}} } \end{lstlisting} In lines \numlist{1;2} we begin the environment and make sure, that the formul\ae\ don't become to big. In lines \numrange{3}{7} the first two reactants are written (lines \numlist{4;6}) and connected with an arrow (line \num{5}). \begin{rxn}[,.8] \setatomsep{1.5em} \branch[,start_left]{ \reactant{\chemfig{=_[::30]-[::-60]-[::60](-[::-60])(-[::120])-[::0]OH}} \arrow[below]{\ce{HBr}}{} \reactant[below]{\chemfig{Br-[::30]-[::-60]=_[::60](-[::-60])-[::60]}} } \end{rxn} \begin{lstlisting}[firstnumber=8] \branch[right=of start_left,start_center,yshift=1em]{ \reactant{\chemname{\chemfig[][scale=.8]{**6(--(-SO_2Cl)---(-)-)}}{tosyle chloride}} \arrow[below]{\ce{NaOH}}{\ce{Zn}} \reactant[below]{\chemfig[][scale=.8]{**6(--(-SO_2Na)---(-)-)}} } \end{lstlisting} In the following lines \numrange{8}{12}, we create the second branch of the synthesis. \begin{rxn}[,.8] \setatomsep{1.5em} \branch[,start_left]{ \reactant{\chemfig{=_[::30]-[::-60]-[::60](-[::-60])(-[::120])-[::0]OH}} \arrow[below]{\ce{HBr}}{} \reactant[below]{\chemfig{Br-[::30]-[::-60]=_[::60](-[::-60])-[::60]}} } \branch[right=of start_left,start_center,yshift=1em]{ \reactant{\chemname{\chemfig[][scale=.8]{**6(--(-SO_2Cl)---(-)-)}}{tosyle chloride}} \arrow[below]{\ce{NaOH}}{\ce{Zn}} \reactant[below]{\chemfig[][scale=.8]{**6(--(-SO_2Na)---(-)-)}} } \end{rxn} \begin{lstlisting}[firstnumber=13] \branch[right=of start_center,start_right,xshift=3em,yshift=-10em]{ \reactant{\chemname{\chemfig{-[::30](-[::60])=_[::-60]-[::60]COOH}}{3-methyl-2-butenoic acid}} \arrow[below]{\ce{CH3OH}}{} \reactant[below]{\chemfig{-[::30](-[::60])=_[::-60]-[::60]CO_2CH_3}} } \branch[below=of start_left,target_one,xshift=5em,yshift=-5em]{ \reactant{\chemfig[][scale=.8]{**6(--(-SO_2-[:30]-[::-60]=_[::60](-[::60])-[::-60])---(-)-)}} } \end{lstlisting} In lines \numrange{13}{20} we create the third branch and the product of the first two branches. \begin{rxn}[,.8] \setatomsep{1.5em} \branch[,start_left]{ \reactant{\chemfig{=_[::30]-[::-60]-[::60](-[::-60])(-[::120])-[::0]OH}} \arrow[below]{\ce{HBr}}{} \reactant[below]{\chemfig{Br-[::30]-[::-60]=_[::60](-[::-60])-[::60]}} } \branch[right=of start_left,start_center,yshift=1em]{ \reactant{\chemname{\chemfig[][scale=.8]{**6(--(-SO_2Cl)---(-)-)}}{tosyle chloride}} \arrow[below]{\ce{NaOH}}{\ce{Zn}} \reactant[below]{\chemfig[][scale=.8]{**6(--(-SO_2Na)---(-)-)}} } \branch[right=of start_center,start_right,xshift=3em,yshift=-10em]{ \reactant{\chemname{\chemfig{-[::30](-[::60])=_[::-60]-[::60]COOH}}{3-methyl-2-butenoic acid}} \arrow[below]{\ce{CH3OH}}{} \reactant[below]{\chemfig{-[::30](-[::60])=_[::-60]-[::60]CO_2CH_3}} } \branch[below=of start_left,target_one,xshift=5em,yshift=-5em]{ \reactant{\chemfig[][scale=.8]{**6(--(-SO_2-[:30]-[::-60]=_[::60](-[::60])-[::-60])---(-)-)}} } \end{rxn} \begin{lstlisting}[firstnumber=21] \branch[below=of target_one,target_two,xshift=6em,yshift=-6em]{ \mesomeric{\chemfig[][scale=.8]{-[::30](-[::60])=^[::-60]-[::60](-[::60]S(=[::90]O)(=[::-90]O)-[::0]**6(---(-)---))-[::-60](-[::0])(-[::-120])-[::60](-[::60,.5,,,white]\ominus)-[::-60]CO_2CH_3}} \arrow[below,,.5]{}{} \arrow[below,,.5]{\ce{KOH}}{} \reactant[below]{\chemname{\chemfig{-[::-30](-[::-60])=^[::60]>[::-60](-[::90,1.2])-[::30,1.2](-[::120,1.2](-[::-60])-[::0])<:[::-30]COOH}}{\emph{trans}-chrysanthemum acid}} } \end{lstlisting} In lines \numrange{21}{26} we create the last branch. \begin{rxn}[,.8] \dummy[start_left] \branch[right=of start_left,start_right,xshift=13em,yshift=-4em]{ \reactant[below]{\chemfig{-[::30](-[::60])=_[::-60]-[::60]CO_2CH_3}} } \branch[below=of start_left,target_one,xshift=5em]{ \reactant{\chemfig[][scale=.8]{**6(--(-SO_2-[:30]-[::-60]=_[::60](-[::60])-[::-60])---(-)-)}} } \branch[below=of target_one,target_two,xshift=6em,yshift=-6em]{ \mesomeric{\chemfig[][scale=.8]{-[::30](-[::60])=^[::-60]-[::60](-[::60]S(=[::90]O)(=[::-90]O)-[::0]**6(---(-)---))-[::-60](-[::0])(-[::-120])-[::60](-[::60,.5,,,white]\ominus)-[::-60]CO_2CH_3}} \arrow[below,,.5]{}{} \arrow[below,,.5]{\ce{KOH}}{} \reactant[below]{\chemname{\chemfig{-[::-30](-[::-60])=^[::60]>[::-60](-[::90,1.2])-[::30,1.2](-[::120,1.2](-[::-60])-[::0])<:[::-30]COOH}}{\emph{trans}-chrysanthemum acid}} } \end{rxn} Finally, the different branches are merged, the second merging arrow gets a label and the environment is ended. \begin{lstlisting}[firstnumber=27] \merge{target_one}{start_left}{start_center} \merge[\ce{NaOCH3}]{target_two}{target_one}{start_right} \end{rxnscheme} \end{lstlisting} \end{document}